A record of changes, improvements, and new features across CLASHub releases.
CLASHub AI Beta
- New Implemented an AI-assisted analysis layer for internal validation, designed to help users query CLASHub resources and summarize curated evidence.
- Improve The AI-assisted workflow is not yet publicly available while validation and institutional review are in progress.
CLASHub AI Beta
- New Added CLASHub AI Beta, allowing users to access CLASHub database-related functions through a natural language interface.
Initial Release
- Data Launched with CLASH data from 25 distinct cell lines or tissues across four model organisms: Human, Mouse, Drosophila, and C. elegans, comprising 146 datasets.
- Data Includes 55 published and 91 newly generated CLASH datasets, with 15 cell lines or tissues not previously reported in the literature.
- Data Includes 50 ZSWIM8 knockout datasets providing insights into target-directed microRNA degradation (TDMD).
- Data Gene expression profiling: 245 RNA-seq datasets from 44 cell lines or tissues.
- Data miRNA expression profiling: 157 miRNA-seq datasets across 25 cell types.
- New Database search interface for CLASH targets, gene expression, and miRNA expression with step-by-step species and cell line selection.
- New Analyzer tool supporting CLASH data processing, miRNA-seq analysis, RNA-seq analysis, and cumulative fraction curve generation.
- New Experimental validation of ATP6V1G1 as a novel TDMD trigger for miR-335, and canonical targets for miR-18a-5p.
